Tsp1 thbs1
WebSecreted TSP1 is a glycoprotein with a molecular mass of 150-180 kDa. Protocols. Product Specific Protocols; WB protocol for Thrombospondin 1 antibody 18304-1-AP: Download protocol: IHC ... tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer. Authors - Dongping Mo. KD …
Tsp1 thbs1
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WebOct 8, 2024 · Approach and Results: Using RNA fluorescent in situ hybridization, we identified macrophages being the major source of TSP1 in human and mouse aneurysmal … WebApr 14, 2024 · TSP1 requires receptor binding to exert its pathogenic effects, and developing selective TSP1-related anti-receptor therapeutics are attractive strategies for future drug development. Indeed, anti-CD47 therapy is now recognised as a major therapeutic arm for treatment of malignancy, and this could be adapted for other diseases which demonstrate …
WebApr 27, 2024 · In addition to an intrinsic role for TSP1 expressed by tumor cells, increased growth of B16 melanomas and F9 testicular teratocarcinomas was observed when implanted in syngeneic mouse strains lacking Thbs1 . As TSP1 is a secreted protein, its abundance in the tumor microenvironment depends on both tumor and stromal cell … WebMay 29, 2024 · Compared to skin from wild-type mice, skin from Thbs1-/-mice had reduced collagen cross-linking and reduced prolysyl oxidase (proLOX) abundance with increased conversion to catalytically active LOX. In vitro, TSP1 bound to both the C-propeptide domain of collagen I and the highly conserved KGHR sequences of the collagen triple-helical …
Web黏附性糖蛋白血小板反应蛋白-1 (thbs1、tsp1) 定位于细胞外基质 (ecm) 中，并且介导细胞和 ecm 之间以及细胞之间的相互作用。 Thrombospondin-1 是一种多结构域的糖基化蛋白，可与各种细胞外组分相互作用，包括基质金属蛋白酶 (MMPs)、胶原、细胞受体、生长因子和细 … Web检测原理： 攸碧艾（YOBIBIO)的ELISA试剂盒采用“夹心法”:将捕获抗体包被于酶标板上，捕获样品及标准品中的靶蛋白，生物素化的检测 S
WebDec 31, 2024 · Two of the altered genes were of particular interest with respect to PMN formation: thrombospondin‐1 (TSP1; THBS1) was the most significantly downregulated gene, while the chondroitin sulfate proteoglycan, …
WebThrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.. Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. … greek writing alphabetWebJul 28, 2024 · In EC-AGO1-KO mice, overexpression of TSP1 substantially attenuated the beneficial phenotype. In human endothelium isolated from donors with obesity or type 2 diabetes mellitus, AGO1 and THBS1 are expressed at higher levels than the healthy controls, supporting a pathological role of this pathway. greek writing historyWebNov 6, 2024 · KRIT1 mutations are the most common cause of cerebral cavernous malformation (CCM). Acute Krit1 gene inactivation in mouse brain microvascular endothelial cells (BMECs) changes expression of multiple genes involved in vascular development. These changes include suppression of Thbs1, which encodes thrombospondin1 (TSP1) … flowerfall westport ctWebJun 25, 2024 · Conversely, male and female Thbs1-null mice showed less weight gain after 5 mo on an HFD or high-carbohydrate/low-fat diet compared with wild-type mice , indicating that the effects of TSP1 on fat-induced weight gain may be time dependent. Obesity-related renal impairment was less in 6-mo-old Thbs1- and Cd36-null mice . flowerfall you are my sunshineWebProduct Summary. The Quantikine Human Thrombospondin-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Thrombospondin-1 in cell culture supernates, serum, plasma, saliva, and human milk. It contains NS0-expressed recombinant human Thrombospondin-1 and has been shown to accurately quantitate the recombinant … greek ww1 uniformWebTHBS, THBS-1, THBS1, TSP, TSP-1, TSP1. Gene ID (Human) 7057. Gene symbol. THBS1. UniProt ID (Human) P07996. Show Less . About This Kit. The Human Thrombospondin-1 (Hu TSP-1) ELISA quantitates Hu TSP-1 in human serum or plasma. The assay will exclusively recognize both natural and recombinant Hu TSP-1. greek writing tool made of metal or boneWebApr 13, 2024 · Thrombospondin 1 (TSP1) ... Li CC, et al. hsa-miR-4443 inhibits myocardial fibroblast proliferation by targeting THBS1 to regulate TGF-beta 1/alpha-SMA/collagen … flower families a go fish game