Read across approach toxicology

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August undefined, 2024

Weba National Center for Computational Toxicology (NCCT), ... any read-across approach should be broadly based in scope or lim-ited to a speciﬁc endpoint. Patlewicz et al. [39,40] discussed the ... WebThe use of toxicity data on a structurally-similar compound to evaluate a substance that has been inadequately tested – the so-called “read-across” approach – is a crucial part of the …

Update on CFSAN Toxicology Activities - Food and …

WebJul 12, 2013 · The Chemical–Biological Read-Across (CBRA) approach infers each compound’s toxicity from both chemical and biological analogues whose similarities are … WebNov 12, 2024 · Chemical grouping and read-across Chemical grouping and read-across approaches take advantage of structural similarities between substances with known toxicology profiles and new chemical entities to infer the expected toxicological behaviour of the latter. 101 This strategy is commonly used in regulatory toxicology as an … ravens photography zenfolio

A strategy for structuring and reporting a read-across prediction of …

WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has … WebComputational Toxicology 3 Definitions: Read-across • Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. • A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across. • WebRead-across (RAx) translates available information from well-characterized chemicals to a substance for which there is a toxicological data gap. The OECD is working on case … simon wincer director

Read-Across to Fill Toxicological Data Gaps - ScienceDirect

An End Point-Specific Framework for Read-Across Analog …

WebMar 10, 2024 · In read-across, available data on chemical structural analogues are used to predict the toxicity potential of the data-poor chemical. This approach has long been recognized by regulatory agencies and used by industry to evaluate the hazards of chemicals for which there are limited direct data. WebSociety of Toxicology (SOT) raven spectra boatWebRead-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU's REACH regulation. raven specialist fishing hooks

"WebJul 8, 2024 · Inspired by the increasingly used read-across approach, we created a new type of QSAR, which is based on similarity of chemicals and not on chemical descriptors. A landscape of the chemical universe using 10 million structures was calculated, when based on Tanimoto indices similar chemicals are close and dissimilar chemicals far from each … " - Read across approach toxicology

Read across approach toxicology

Simona Kovarich - Senior Regulatory Toxicology Expert - Merck …

WebDec 21, 2024 · The Strategic Plan has three core components: (1) identifying, developing and integrating NAMs for TSCA decisions; (2) building confidence that the NAMs are scientifically reliable and relevant for TSCA decisions; and (3) implementing the reliable and relevant NAMs for TSCA decisions. On this page: Implementing the Strategic Plan WebMar 27, 2024 · We developed Generalized Read-Across (GenRA) ( Shah et al., 2016) for automated read-across prediction of a property of a chemical (called the target) as a similarity weighted average of the same property from analogues (also referred to as source analogues) ( Low et al., 2013 ).

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WebWe present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active … WebApr 30, 2024 · defines grouping of substances and read-across approach as: “ Substances whose physicochemical, toxicological and ecotoxicological properties are likely to be …

WebFeb 6, 2024 · Toxicology and Environmental Research and Consulting, Dow Chemical, Midland, Michigan, USA. Search for more papers by this author. Lennart Weltje, ... In addition, the degree of validation needed to provide sufficient confidence in a given read-across approach has to be decided. Another complicating factor is the difference in validation ...

WebJan 1, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. ... The read-across approach starts with structural ... WebRead-across is one approach frequently used in the risk assessment of substances that lack information on their physical-chemical or toxicological properties, or their environmental …

WebComputational Toxicology Generalised Read-Across GenRA, research, implementation and practical application. ToxPi. PRIORITIZATION. Interactive Chemica Sl afety for Sustainability Web Application TOXCAST iCSS v0.5 Tool Tip Description of Assays (Data) or . Prioritization Mode whatever is being hovered over Desc Summary Log 80-05-7 80-05-1 80-05 ...

WebOct 1, 2024 · A workshop on the “Read-across: Principle, case study and its potential regulatory application in China”, organized by the Chemical Risk Assessment Specialty … ravensperch literary magazineWebDec 2, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. In read-across, structure-related parameters are compared between a target chemical with insufficient test data and one or more materials with sufficient data. Recent advances have focused on … ravens play by play radioWebproposed read-across case, resulting in an output which is suitable for subsequent regulatory consideration of the read-across case. The approach reflects both a need to … simon wine barWebread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach ravens play clock expiredWebJan 1, 2024 · These preliminary biological data-driven read-across studies highlight the road to the new generation of read-across approaches that can be applied in chemical safety … simon wineWebJun 10, 2013 · Considerations before embarking on a read-across approach have been discussed at length elsewhere [16,17,19, 20, 27]. The types of considerations vary to a degree depending on the decision context ... ravens players 2021WebComputational Toxicology. Background & definitions • Read-across describes one of the data gap filling techniques used within analogue and category approaches • “Analogue approach” refers to grouping based on a very limited number of chemicals (e.g. target substance) + source substance) • “Category approach” is used when grouping ... ravens play by play espn