WebCustom Seiko Black Sumo Dial Scuba Divers Day Date Automatic Watch 6309 Mod. 1988 Original. Refurbished. Serviced, Pressure Tested. Condition: Pre-owned. “This original Seiko Diver's watch has been expertly polished and rebrushed, and the large ”... Read more. Time left: 8d 22h 04/23, 01:16 PM. Web6 aug. 2024 · SUMO modification is an evolutionarily conserved pathway that is predominantly found within the nucleus of all eukaryotes. SUMOs are a class of structurally ubiquitin like proteins (~12 kDa), and the amino acid sequence of SUMO1 is only 18% identical to ubiquitin. SUMO1, 2 and 3 are the best-studied members of this class.
SUMO conjugation – a mechanistic view - De Gruyter
Web29 jun. 2006 · Distinct post-translational modifications of the target protein can affect its sumoylation. A) Competition with other lysine-directed modifications such as ubiquitinylation of acetylation abolishes sumoylation. B) Phosphorylation can act both as a positive and a negative regulator of sumoylation. Web20 feb. 2005 · Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences … thompson italian old town
SUMO: a regulator of gene expression and genome integrity
Web1 feb. 2003 · Search life-sciences literature (Over 39 million articles, preprints and more) WebSUMO modification sites present in the N-terminal regions of SUMO-2 and SUMO-3 are utilized by SAE1/SAE2 and Ubc9 to form polymeric chains of SUMO-2 and SUMO-3 on protein substrates in vitro, and SUMO-2 chains are detected in vivo. The ability to form polymeric chains is not shared by SUMO-1. Thus, although all SUMO species share the … Web7 apr. 2024 · Our current knowledge of sumoylation as a covalent modification dates back to these early studies on nuclear transport, which also provided initial clues on the distinct biochemical functions of this ubiquitin-like modification, especially those pertaining to subcellular target localization. uk to schiphol airport