WebOct 10, 2024 · The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a central role in cell survival and function. STAT3 has been demonstrated to participate in the maintenance of bone homeostasis in osteoblasts, but its role in osteoclasts in vivo remains poorly defined. Here, we generated a conditional knockout mouse model … WebJan 20, 2024 · As shown in Fig. Fig.5g, 5g, STAT3, along with protein arginine methyltransferase-5 (PRMT5), a key transcriptional cofactor of STAT3 that can improve its transcriptional activity to downstream targeted genes, appeared in FOXD2-AS1 precipitates, suggesting that FOXD2-AS1, STAT3, and PRMT5 were consistent with the notion of a …
Erk1/2 activation and modulation of STAT3 signaling in oral cancer
WebApr 12, 2024 · Hormone receptor-positive and HER2-negative (HR+/HER2−; luminal A) tumors are prevalent in breast cancer. Our past studies demonstrated that “TME Stimulation” (estrogen + TNFα + EGF, representing three arms of the tumor microenvironment, TME) has enriched metastasis-forming cancer stem cells (CSCs) in … WebMar 5, 2015 · Phosphorylation at Tyr705 activates STAT3, inducing dimerization, nuclear translocation, and DNA binding. In this study, we investigated whether receptor-type tyrosine-protein phosphatase κ (PTPRK), the only protein tyrosine phosphatase at 6q that contains a STAT3-specifying motif, negatively regulates STAT3 activation in NKTCL. high frosch
Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb - Cell Signaling Technology
WebApr 11, 2024 · We found that Stat3 IEC mice exhibited severe colon inflammation, lower expression of Ki-67 and mucus density than Stat3fl/fl controls do. Furthermore, our results indicated that B. fragilis promoted IL-22 production, and increased the percentage of IL-22-secreting type 3 innate lymphocytes (ILC3) in colitis. ... (CST #9145, Danvers, MA, USA ... WebThis Cell Signaling Technology antibody is conjugated to Alexa Fluor ® 647 fluorescent dye and tested in-house for direct flow cytometric analysis of human cells. The unconjugated Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb #9145 reacts with Phospho-Stat3 (Tyr705) from human, mouse and rat. WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-STAT3 (phospho S727) antibody [E121-31] (ab32143) Research with confidence – consistent and reproducible results with every batch. Long … howick pet grooming