WebMay 5, 2024 · Genotype-based recommendations seem to mirror CPIC simvastatin guidelines. The primary outcome is a change in plasma LDL-cholesterol level at 1 year. … WebNational Center for Biotechnology Information
The frequency of SLCO1B1*5 polymorphism genotypes among …
WebJul 12, 2024 · Usual Adult Dose for Prevention of Cardiovascular Disease Initial dose: 10 to 20 mg orally once a day High-risk patients may initiate at 40 mg orally once a day Maintenance dose: 5 to 40 mg orally once a day Maximum dose: 40 mg/day WebAug 18, 2016 · Aim 1 (Drug safety): To determine the impact of SLCO1B1 pharmacogenetic testing on concordance with Clinical Pharmacogenetics Implementation Consortium (CPIC) pharmacogenetic guidelines for safe simvastatin prescribing and on the incidence of statin-related myopathy in VA (drug safety). pictools ipa
Effects of Simvastatin on Biomarkers - ClinicalTrials.gov
WebJul 12, 2024 · Restricted Use of Simvastatin 80 mg/day: Simvastatin 80 mg dose should only be used in patients who have taken this dose chronically (e.g., for 12 months or … WebTacrolimus is the mainstay immunosuppressant drug used after solid organ and hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and intermediate metabolizers) generally have decreased dose-adjusted trough concentrations of tacrolimus as compared with those who are CYP3A5 nonexpressers (poor … WebFeb 13, 2024 · The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms … CPIC assigns CPIC levels to genes/drugs with (1) PharmGKB Clinical Annotation … topcon gx-55