Circanks1b

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August undefined, 2024

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Circular RNA circANKS1B as the Sponge of miR-152-3p Promotes …

WebFeb 8, 2024 · The expression of circANKS1B and miR‐152‐3p was analyzed by real‐time quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR). Cell migration … WebDec 3, 2024 · Consequently, circANKS1B induces EMT by sponging miR-148a-3p and miR-152-3p. 83 Moreover, upregulated circANKS1B expression, which promotes migration and invasion of cancer cells, served as an independent risk factor for poor OS in patients with BC. 83 Other circRNAs, such as circAGFG1, circKIF4A, and circPLK1, are also … pophuman scan

Cancers Free Full-Text Mechanisms Regulating Abnormal …

We characterized circRNA transcripts by performing RNA-seq on ribosomal RNA-depleted total RNA from three pairs of TNBC and adjacent normal tissues. In all, 69,815 distinct circRNAs were found in this study and 87% were derived from exons, and the others were derived from introns, intergenic region and 3′ … See more To dissect the underlying mechanism by which circANKS1B induces EMT to promote breast cancer metastasis, we mainly focus on “miRNA sponges” because of … See more USF1, a transcription factor, belongs to the basic helix-loop-helix leucine zipper (bHLH-LZ) family which regulates different genes expression by … See more WebMay 10, 2024 · CircANKS1B used miR-148a-3p and miR-152-3p to intensify the expression of the transcription factor USF1, consequently activating the TGF-β1/Smad regulatory circuit to increase EMT. Studies declared that circNR3C2 [ 107 ], hsa_circ_0006220, circTADA2A-E6 and circITCH had a negative impression on the regulation of metastasis through … http://jcmp.yzu.edu.cn/ share screen on tv wifi

Circular RNA circANKS1B acts as a sponge for miR-152 …

circ-ANKS1B facilitates osteosarcoma cell proliferation and ...

WebSep 3, 2024 · CircANKS1B has been demonstrated to be involved in several diseases, like breast cancer and colorectal cancer (Zeng et al., 2024; Li et al., 2024). In Zeng et al.’s (2024) research, they found that circANKS1B could induce epithelial-to-mesenchymal transition (EMT) via activating TGF-β1 signaling pathway in breast cancer. WebESRP1 mediated alternative splicing of target genes, including CD44, FGFR, PTBP1, LYN, ENAH, SPAG1 and ZMYND8, results in cancer progression. In addition, ESRP1 also regulates circularization and biogenesis of circular RNAs such as circUHRF1, circNOL10 and circANKS1B, whose expressions have been identified as key factors in various … pop huge blackheadsWebSep 16, 2024 · The upregulated circANKS1B has been implicated in promoting breast cancer invasion and metastasis. The pro-metastatic effect of circANKS1B is mediated through the interaction with miR-148a-3p … share screen on tv wireless

"WebJul 15, 2024 · The high expression of circANKS1B is closely related to the clinical stage and is an independent risk factor for the overall survival rate of breast cancer patients. At the same time, breast cancer patients with high expression of ESRP1 also have a poor overall survival . In oral squamous cell carcinoma (OSCC), circUHRF1 is significantly up ... " - Circanks1b

Circanks1b

WebMay 1, 2024 · CircANKS1B has been reported to be increased in breast cancer. Methods: Real-time polymerase chain reaction (real-time PCR) assay was used to measure … WebMar 10, 2024 · Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this …

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WebMethods: CircANKS1B (a circRNA originated from exons 5 to 8 of the ANKS1B gene, hsa_circ_0007294) was identified by RNA-sequencing and validated by qRT-PCR and Sanger sequencing. Clinical breast cancer samples were used to evaluate the expression of circANKS1B and its associations with clinicopathological features and prognosis.

WebScale bar = 10 μm. g qRT-PCR for the expression of circANKS1B in 40 normal tissues and 165 breast cancer tissues. h Analysis of circANKS1B expression in breast cancer patients with or without ... WebNov 19, 2024 · Increased circANKS1B expression was closely associated with lymph node metastasis and advanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients. Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro and in vivo by inducing epithelial-to ...

WebFeb 11, 2024 · Similarly, enrichment of circANKS1B in HPV-positive cervical cancer exosomes may play a role in influencing cellular migration and invasion. circANKS1B increases the expression of transcription factor USF1, which upregulates TGF-β1 expression resulting in activated TGF-β1/Smad signaling and EMT in breast cancer . WebFurthermore, the knockdown of circANKS1B sensitized OSCC cells to cisplatin by suppressing cell viability and increasing cell apoptosis and caspase-3 activity. …

Webcancer patients [18]. Furthermore, circANKS1B also acts as a sponge of miR-149 to promote colorectal cancer cell migration and invasion [19]. Analogously, circANKS1B can sponge miR-148-3p and miR-152-3p to activate the TGF-β signaling to accelerate cancer metastasis [18]. Nevertheless, the function of circANKS1B

WebMay 23, 2024 · CircANKS1B promotes cell migration and invasion in CRC. To analyze the role of circANKS1B in CRC, we used circANKS1B … pop hyde cheshireWebMay 11, 2024 · The results suggest that circANKS1B is an interesting circRNAs to study in order to find alternative therapeutic strategies for inhibiting breast cancer metastasis. CircRNAs in lung cancer Lung cancer is one of the most common cancers in the world with 5-year survival rates varying from 92 to 0%, depending on disease stage at diagnosis 58 . share screen on two macbooksWebBackground: As circular RNAs (circRNAs) have been found to significantly involve in the onset and progression of multiple malignant tumors including breast cancer (BC), this study aims at evaluating the diagnostic and prognostic values of circRNAs in this malady. Methods: Available databases were thoroughly searched to collect studies on the … share screen on webex on macWebBackground: A growing number of studies indicate that circular RNAs (circRNAs) play critical roles in human diseases, and show great potential as biomarkers and therapeutic … share screen on tv windows 11WebFeb 21, 2024 · Breast cancer is the second most reported cancer in women with high mortality causing millions of cancer-related deaths annually. Early detection of breast cancer intensifies the struggle towards discovering, developing, and optimizing diagnostic biomarkers that can improve its prognosis and therapeutic outcomes. Breast cancer … pop human hair headband fallWebNov 19, 2024 · CircANKS1B (a circRNA originated from exons 5 to 8 of the ANKS1B gene, hsa_circ_0007294) was identified by RNA-sequencing and validated by qRT-PCR and … pop hutchinsonWebNov 19, 2024 · Increased circANKS1B expression was closely associated with lymph node metastasis and advanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients. Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro and in vivo by inducing epithelial-to ... pophw on bing